Neutrophil extracellular trap formation is associated with IL-1β and autophagy-related signaling in gout.
|Τίτλος||Neutrophil extracellular trap formation is associated with IL-1β and autophagy-related signaling in gout.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Mitroulis I, Kambas K, Chrysanthopoulou A, Skendros P, Apostolidou E, Kourtzelis I, Drosos GI, Boumpas DT, Ritis K|
Gout is a prevalent inflammatory arthritis affecting 1-2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1β (IL-1β). Since neutrophils play a major role in gout we sought to determine whether their activation may involve the formation of proinflammatory neutrophil extracellular traps (NETs) in relation to autophagy and IL-1β.
|Short Title||PLoS One|