Neutrophil extracellular trap formation is associated with IL-1β and autophagy-related signaling in gout.

ΤίτλοςNeutrophil extracellular trap formation is associated with IL-1β and autophagy-related signaling in gout.
Publication TypeJournal Article
Year of Publication2012
AuthorsMitroulis I, Kambas K, Chrysanthopoulou A, Skendros P, Apostolidou E, Kourtzelis I, Drosos GI, Boumpas DT, Ritis K
JournalPloS one
Volume6
Issue12
Paginatione29318
Date Published2011
Abstract

Gout is a prevalent inflammatory arthritis affecting 1-2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1β (IL-1β). Since neutrophils play a major role in gout we sought to determine whether their activation may involve the formation of proinflammatory neutrophil extracellular traps (NETs) in relation to autophagy and IL-1β.

URLhttp://dx.plos.org/10.1371/journal.pone.0029318
DOI10.1371/journal.pone.0029318
Short TitlePLoS One