Neutrophil extracellular traps regulate IL-1β-mediated inflammation in familial Mediterranean fever.
|Τίτλος||Neutrophil extracellular traps regulate IL-1β-mediated inflammation in familial Mediterranean fever.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Apostolidou E, Skendros P, Kambas K, Mitroulis I, Konstantinidis T, Chrysanthopoulou A, Nakos K, Tsironidou V, Koffa M, Boumpas DT, Ritis K|
|Journal||Annals of the rheumatic diseases|
|Date Published||2014 Sep 26|
Inflammatory attacks of familial Mediterranean fever (FMF) are characterised by circulation and influx of high number of polymorphonuclear neutrophils (PMN) in the affected sites and profound therapeutic effect of IL-1β inhibitors. We investigated the role of neutrophil extracellular traps (NET) in the pathogenesis of FMF, and their involvement in IL-1β production.
|Short Title||Ann Rheum Dis|