Neutrophil extracellular traps regulate IL-1β-mediated inflammation in familial Mediterranean fever.

ΤίτλοςNeutrophil extracellular traps regulate IL-1β-mediated inflammation in familial Mediterranean fever.
Publication TypeJournal Article
Year of Publication2014
AuthorsApostolidou E, Skendros P, Kambas K, Mitroulis I, Konstantinidis T, Chrysanthopoulou A, Nakos K, Tsironidou V, Koffa M, Boumpas DT, Ritis K
JournalAnnals of the rheumatic diseases
Date Published2014 Sep 26
ISSN0003-4967
Abstract

Inflammatory attacks of familial Mediterranean fever (FMF) are characterised by circulation and influx of high number of polymorphonuclear neutrophils (PMN) in the affected sites and profound therapeutic effect of IL-1β inhibitors. We investigated the role of neutrophil extracellular traps (NET) in the pathogenesis of FMF, and their involvement in IL-1β production.

URLhttp://ard.bmj.com/cgi/pmidlookup?view=long&pmid=25261578
DOI10.1136/annrheumdis-2014-205958
Short TitleAnn Rheum Dis