Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis.
|Τίτλος||Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Choulaki C, Papadaki G, Repa A, Kampouraki E, Kambas K, Ritis K, Bertsias G, Boumpas DT, Sidiropoulos P|
|Journal||Arthritis research & therapy|
|Date Published||2015 Sep 19|
Interleukin-1β (IL-1β) is a major inflammatory cytokine, produced predominantly by innate immune cells through NLRP3-inflammasome activation. Both intrinsic and extrinsic danger signals may activate NLRP3. Genetic variations in NLRP3-inflammasome components have been reported to influence rheumatoid arthritis (RA) susceptibility and severity. We sought to assess the activity of NLRP3-inflammasome in patients with active RA compared to healthy individuals.
|Short Title||Arthritis Res Ther|