Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis.

ΤίτλοςEnhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis.
Publication TypeJournal Article
Year of Publication2015
AuthorsChoulaki C, Papadaki G, Repa A, Kampouraki E, Kambas K, Ritis K, Bertsias G, Boumpas DT, Sidiropoulos P
JournalArthritis research & therapy
Volume17
Pagination257
Date Published2015 Sep 19
ISSN1478-6354
Abstract

Interleukin-1β (IL-1β) is a major inflammatory cytokine, produced predominantly by innate immune cells through NLRP3-inflammasome activation. Both intrinsic and extrinsic danger signals may activate NLRP3. Genetic variations in NLRP3-inflammasome components have been reported to influence rheumatoid arthritis (RA) susceptibility and severity. We sought to assess the activity of NLRP3-inflammasome in patients with active RA compared to healthy individuals.

URLhttp://arthritis-research.com/content/17//257
DOI10.1186/s13075-015-0775-2
Short TitleArthritis Res Ther