NETopathies? Unraveling the Dark Side of Old Diseases through Neutrophils.
|Τίτλος||NETopathies? Unraveling the Dark Side of Old Diseases through Neutrophils.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Mitsios A, Arampatzioglou A, Arelaki S, Mitroulis I, Ritis K|
|Journal||Frontiers in immunology|
|Date Published||2017 Jan 11|
Neutrophil extracellular traps (NETs) were initially described as an antimicrobial mechanism of neutrophils. Over the last decade, several lines of evidence support the involvement of NETs in a plethora of pathological conditions. Clinical and experimental data indicate that NET release constitutes a shared mechanism, which is involved in a different degree in various manifestations of non-infectious diseases. Even though the backbone of NETs is similar, there are differences in their protein load in different diseases, which represent alterations in neutrophil protein expression in distinct disorder-specific microenvironments. The characterization of NET protein load in different NET-driven disorders could be of significant diagnostic and/or therapeutic value. Additionally, it will provide further evidence for the role of NETs in disease pathogenesis, and it will enable the characterization of disorders in which neutrophils and NET-dependent inflammation are of critical importance.
|Short Title||Front Immunol|